Sugi Predict

Sugi Predict / Compounds / Guanosine

Guanosine

Guanosine

SCHEMBL8199835

Nc1nc2[nH]cnc2c(=O)[nH]1.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.Nc1ncnc2[nH]cnc12.Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.O=c1[nH]c(=O)c2[nH]cnc2[nH]1.OC[C@H]1O[C@@H](n2cnc3c(O)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3

The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 known ✓ P0DMS8 1/20 0.50
▸ ADORA2A known ✓ P29274 1/20 0.50
▸ ADORA2B known ✓ P29275 1/20 0.50
▸ ADORA1 known ✓ P30542 1/20 0.50
▸ DPP4 P27487 1/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ SLC28A1 O00337 1/20 0.50
▸ MAP3K7 O43318 1/20 0.50
▸ SLC28A2 O43868 1/20 0.50
▸ GAPDH P04406 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ STAT6 P42226 1/20 0.50
▸ PI4KA P42356 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ SMN1; SMN2 Q16637 1/20 0.50
▸ PI4K2B Q8TCG2 1/20 0.50
▸ DOT1L Q8TEK3 1/20 0.50
▸ SLC29A1 Q99808 1/20 0.50
▸ PI4K2A Q9BTU6 1/20 0.50
▸ SLC28A3 Q9HAS3 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Adenosine SCHEMBL21854748 0.92 ADORA3 (0.52) DPP4MEN1SLC28A1MAP3K7SLC28A2
Guanosine SCHEMBL8199838 0.90 DPP4 (0.49) DPP4MEN1SLC28A1MAP3K7SLC28A2
Adenosine SCHEMBL6417817 0.90 ADORA3 (0.62) DPP4MEN1SLC28A1MAP3K7SLC28A2
Adenosine SCHEMBL4115282 0.86 ADORA3 (0.67) DPP4MEN1SLC28A1MAP3K7SLC28A2
Adenosine SCHEMBL4576858 0.86 ADORA3 (0.67) DPP4MEN1SLC28A1MAP3K7SLC28A2
Guanosine SCHEMBL3492467 0.86 HPGD (0.59) ADORA2AADORA2BHPGD
Guanosine SCHEMBL9138595 0.85 HPGD (0.60) DPP4MEN1SLC28A1MAP3K7SLC28A2
Guanosine SCHEMBL8199614 0.85 ADORA3 (0.68) DPP4MEN1SLC28A1MAP3K7SLC28A2
Guanosine SCHEMBL3926761 0.85 ADORA3 (0.68) DPP4MEN1SLC28A1MAP3K7SLC28A2
Inosine SCHEMBL1676888 0.85 ADORA3 (0.52) DPP4MEN1SLC28A1MAP3K7SLC28A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013288-A NUCLEOSIDE-DECOMPOSED WORT IS PRODUCED BY CAUSING NUCLEOSIDE PHOSPHORYLASE OR NUCLEOSIDASE TO ACT ON WORT TO DECOMPOSE THE PURINE NUCLEOSIDES CONTAINED IN THE WORT INTO PURINE BASES, AND MANUFATURING THE BEER USING NUCLEOSIDE-DECOMPOSED WORT SUNTORY LIMITED (JP) 2000-01-11 — — US disclosed