Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.49 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.49 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.49 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.49 |
| ▸ | GAPDH | P04406 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL21854749 | 0.94 | ADORA3 (0.54) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Guanosine SCHEMBL27641680 | 0.92 | ADORA3 (0.49) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Guanosine SCHEMBL8199835 | 0.90 | DPP4 (0.50) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Adenosine SCHEMBL6417817 | 0.89 | ADORA3 (0.62) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Guanosine SCHEMBL936682 | 0.87 | HPGD (0.55) | ADORA2AADORA2BHPGD | |
| Inosine SCHEMBL3799120 | 0.87 | PAX8 (0.49) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Inosine SCHEMBL28379793 | 0.87 | ADORA3 (0.55) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Adenosine SCHEMBL21854748 | 0.86 | ADORA3 (0.52) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Adenosine SCHEMBL3429274 | 0.86 | ADORA3 (0.66) | DPP4MEN1SLC28A1MAP3K7SLC28A2 | |
| Guanosine SCHEMBL9138605 | 0.86 | HPGD (0.58) | DPP4MEN1SLC28A1MAP3K7SLC28A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013288-A | NUCLEOSIDE-DECOMPOSED WORT IS PRODUCED BY CAUSING NUCLEOSIDE PHOSPHORYLASE OR NUCLEOSIDASE TO ACT ON WORT TO DECOMPOSE THE PURINE NUCLEOSIDES CONTAINED IN THE WORT INTO PURINE BASES, AND MANUFATURING THE BEER USING NUCLEOSIDE-DECOMPOSED WORT | SUNTORY LIMITED (JP) | 2000-01-11 | — | — | US | disclosed |