Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198570 | 0.89 | HTR2C (0.47) | SMN1; SMN2MAPTHTR2CALDH1A1 | |
| SCHEMBL8199695 | 0.88 | SLC6A2 (0.46) | HTR2C | |
| SCHEMBL8202264 | 0.87 | CHRM4 (0.50) | SMN1; SMN2HTR2C | |
| SCHEMBL8191651 | 0.87 | MCHR1 (0.48) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL8200603 | 0.86 | HTR2C (0.49) | SMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL8588802 | 0.85 | HTR2C (0.48) | LMNAMAPTHTR2C | |
| SCHEMBL8198781 | 0.84 | HTR2C (0.46) | HTR2CALDH1A1 | |
| SCHEMBL8203525 | 0.84 | SIGMAR1 (0.46) | HTR2CALDH1A1 | |
| SCHEMBL8191618 | 0.83 | HTR2C (0.50) | MAPTPOLBHTR2CALDH1A1 | |
| SCHEMBL8199972 | 0.83 | HTR2C (0.46) | HTR2CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |