Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.50 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8198570 | 0.93 | HTR2C (0.47) | CHRM4SLC5A7HTR2CSMN1; SMN2OPRM1 | |
| SCHEMBL8191651 | 0.91 | MCHR1 (0.48) | SLC5A7HTR2CSMN1; SMN2OPRM1OPRK1 | |
| SCHEMBL8199695 | 0.90 | SLC6A2 (0.46) | HTR2COPRM1OPRK1DRD2 | |
| SCHEMBL8198781 | 0.88 | HTR2C (0.46) | CHRM4HTR2CMEN1KMT2ADRD2 | |
| SCHEMBL8203525 | 0.87 | SIGMAR1 (0.46) | CHRM4HTR2CMEN1KMT2ASIGMAR1 | |
| SCHEMBL8200656 | 0.87 | SMN1; SMN2 (0.53) | HTR2CSMN1; SMN2 | |
| SCHEMBL8200603 | 0.86 | HTR2C (0.49) | CHRM4SLC5A7HTR2CSMN1; SMN2HTR7 | |
| SCHEMBL8199074 | 0.86 | HTR2C (0.48) | HTR2CSMN1; SMN2OPRM1OPRK1HTR7 | |
| SCHEMBL8588802 | 0.85 | HTR2C (0.48) | SLC5A7HTR2COPRM1OPRK1DRD2 | |
| SCHEMBL8199804 | 0.84 | HTR2C (0.49) | HTR2COPRM1OPRK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |