Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 12/20 | 0.52 |
| ▸ | APOB | P04114 | 11/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207493 | 0.91 | ITGB3 (0.55) | MTTPAPOBITGB3ITGA2BKMT2A | |
| SCHEMBL8208394 | 0.83 | APOB (0.49) | MTTPAPOBTRPV4JAK2JAK3 | |
| SCHEMBL8208323 | 0.82 | APOB (0.58) | MTTPAPOBITGB3ITGA2B | |
| SCHEMBL8211067 | 0.82 | MTTP (0.61) | MTTPAPOBITGB3ITGA2B | |
| SCHEMBL8587342 | 0.81 | APOB (0.52) | MTTPAPOBJAK2JAK3PTK2 | |
| SCHEMBL9232371 | 0.81 | NAMPT (0.52) | MTTPAPOBKMT2A | |
| SCHEMBL8208665 | 0.81 | MTTP (0.57) | MTTPAPOBITGB3ITGA2B | |
| SCHEMBL7928573 | 0.80 | MTTP (0.59) | MTTPAPOB | |
| SCHEMBL8506927 | 0.80 | MTTP (0.59) | MTTPAPOBITGB3ITGA2B | |
| SCHEMBL8227337 | 0.80 | APOB (0.56) | MTTPAPOBITGB3ITGA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | disclosed |