Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.44 |
| ▸ | ARG2 | P78540 | 4/20 | 0.40 |
| ▸ | ARG1 | P05089 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220222 | 0.86 | NOS2 (0.49) | NOS2NOS1NOS3ARG2ARG1 | |
| SCHEMBL7912026 | 0.83 | NOS2 (0.47) | NOS2NOS1NOS3ARG2ARG1 | |
| SCHEMBL7911865 | 0.81 | NOS2 (0.44) | NOS2NOS1NOS3ARG2ARG1 | |
| SCHEMBL7908808 | 0.81 | NOS2 (0.44) | NOS2NOS1NOS3ARG2ARG1 | |
| SCHEMBL7901737 | 0.77 | NOS1 (0.41) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7911875 | 0.74 | NOS3 (0.43) | NOS2NOS1NOS3CYP1A2CYP3A4 | |
| SCHEMBL7220293 | 0.73 | NOS2 (0.54) | NOS2NOS1NOS3ARG2ARG1 | |
| SCHEMBL7911979 | 0.72 | L3MBTL1 (0.44) | NOS2NOS1NOS3KMT2A | |
| Hydrochloric Acid SCHEMBL8201921 | 0.71 | L3MBTL1 (0.43) | NOS2NOS1NOS3KMT2A | |
| SCHEMBL7226686 | 0.70 | NOS2 (0.50) | NOS2NOS1NOS3ARG2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | claimed |