Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063022 | 0.81 | GRM2 (0.45) | HRH3 | |
| SCHEMBL8201966 | 0.80 | HRH3 (0.42) | HRH3AGTR1AGTR2L3MBTL1ENPP2 | |
| SCHEMBL8210234 | 0.77 | SLC34A2 (0.36) | HRH3AGTR1AGTR2L3MBTL1 | |
| SCHEMBL3070704 | 0.73 | GRM2 (0.41) | — | |
| SCHEMBL3067966 | 0.70 | GRM2 (0.46) | HRH3 | |
| SCHEMBL4778780 | 0.67 | TSHR (0.42) | L3MBTL1 | |
| SCHEMBL8727939 | 0.66 | ALDH1A1 (0.46) | — | |
| SCHEMBL709135 | 0.66 | ESR1 (0.42) | — | |
| SCHEMBL8730874 | 0.66 | ALDH1A1 (0.46) | — | |
| SCHEMBL1728235 | 0.65 | HTR1A (0.40) | HTR1AADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032191-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (US) | 2008-03-20 | — | — | WO | disclosed |