Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HTR5A | P47898 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759483 | 0.80 | TRPA1 (0.40) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL309794 | 0.76 | MAPT (0.50) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL2552199 | 0.76 | MEN1 (0.40) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL4970782 | 0.71 | TRPA1 (0.38) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL8202269 | 0.70 | DRD2 (0.42) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL8203995 | 0.70 | BCHE (0.44) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL3370805 | 0.68 | SMN1; SMN2 (0.44) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL8203046 | 0.68 | GAA (0.41) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL11162416 | 0.67 | MEN1 (0.44) | MEN1KMT2AUSP2PPARGKEAP1 | |
| SCHEMBL3521082 | 0.67 | DRD2 (0.43) | MEN1KMT2AHSD17B10TRPA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103715-A | COMPOUNDS THAT BIND TO THE DOPAMINE D4 RECEPTOR AND THEIR USE AS ANXIOLYTIC AGENTS, TREATMENT FOR SCHIZOPHRENIA, AND DRUG SCREENING; SIDE EFFECT REDUCTIOON | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-15 | — | — | US | disclosed |
| US-5968478-A | DIBENZOTHIEPINE AS NEUROTRANSMITTERS AND FOR DRUG SCREENING AND TREATMENT OF SCHIZOPHRENIA | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-10-19 | — | — | US | disclosed |
| US-5538965-A | TREATMENT OF PSYCHOLOGICAL DISORDERS SUCH AS SCHIZOPHRENIA AND ANXIETY | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 1996-07-23 | — | — | US | disclosed |
| WO-1996018622-A1 | N-METHYL PIPERAZINE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY | ALLELIX BIOPHARMACEUTICALS INC. (US) | 1996-06-20 | — | — | WO | disclosed |