Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203121 | 0.88 | DRD3 (0.43) | DRD3HTR2CCARM1PRMT6DRD2 | |
| SCHEMBL8588349 | 0.88 | SIGMAR1 (0.44) | DRD3HTR2CDRD2SIGMAR1CHRM4 | |
| SCHEMBL8200419 | 0.88 | SIGMAR1 (0.44) | DRD3HTR2CDRD2SIGMAR1CHRM4 | |
| SCHEMBL8589678 | 0.88 | SIGMAR1 (0.44) | DRD3HTR2CDRD2SIGMAR1CHRM4 | |
| SCHEMBL8200044 | 0.86 | SIGMAR1 (0.47) | DRD3DRD2SIGMAR1CHRM4DRD4 | |
| SCHEMBL8198484 | 0.85 | HTR2C (0.42) | DRD3HTR2CCARM1SLC18A3SIGMAR1 | |
| SCHEMBL8200547 | 0.84 | HTR2C (0.48) | DRD3HTR2CDRD2SIGMAR1OPRM1 | |
| SCHEMBL8200402 | 0.83 | HTR2C (0.48) | DRD3HTR2CDRD2SLC18A3PRCP | |
| SCHEMBL8203690 | 0.82 | PRCP (0.42) | DRD3HTR2CDRD2SLC18A3ADRA1A | |
| SCHEMBL8199643 | 0.82 | CCR5 (0.48) | DRD3HTR2CCARM1PRMT6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |