Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CCR2 | P41597 | 5/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8588349 | 0.91 | SIGMAR1 (0.44) | HTR2CDRD3SIGMAR1CHRM4MEN1 | |
| SCHEMBL8589678 | 0.91 | SIGMAR1 (0.44) | HTR2CDRD3SIGMAR1CHRM4MEN1 | |
| SCHEMBL8200419 | 0.91 | SIGMAR1 (0.44) | HTR2CDRD3SIGMAR1CHRM4MEN1 | |
| SCHEMBL8200050 | 0.90 | CCR2 (0.55) | CCR2 | |
| SCHEMBL8203690 | 0.89 | PRCP (0.42) | HTR2CDRD3CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8200044 | 0.89 | SIGMAR1 (0.47) | DRD3SIGMAR1CHRM4MEN1TP53 | |
| SCHEMBL8200402 | 0.86 | HTR2C (0.48) | HTR2CDRD3SIGMAR1CHRM4SLC18A3 | |
| SCHEMBL8203121 | 0.85 | DRD3 (0.43) | HTR2CDRD3CARM1SLC18A3 | |
| SCHEMBL8203423 | 0.85 | DRD3 (0.43) | HTR2CDRD3SIGMAR1CHRM4CARM1 | |
| SCHEMBL8199643 | 0.83 | CCR5 (0.48) | HTR2CDRD3SIGMAR1CARM1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |