Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200402 | 0.89 | HTR2C (0.48) | CCR5SLC18A3HTR2CHTR7SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8199293 | 0.86 | HTR2C (0.46) | SLC18A3HTR2CHTR7SIGMAR1PRCP | |
| SCHEMBL8203549 | 0.84 | HTR2C (0.43) | HTR2CHTR7DRD2DRD3 | |
| SCHEMBL8203504 | 0.83 | HTR2C (0.42) | SLC18A3HTR2CHTR7SIGMAR1CARM1 | |
| SCHEMBL8198484 | 0.83 | HTR2C (0.42) | SLC18A3HTR2CHTR7SIGMAR1CARM1 | |
| SCHEMBL8200968 | 0.83 | CCR5 (0.44) | CCR5SLC18A3HTR2CHTR7SIGMAR1 | |
| SCHEMBL8192538 | 0.83 | PRCP (0.56) | CCR5SLC18A3HTR2CPRCP | |
| SCHEMBL8199832 | 0.83 | PRCP (0.56) | CCR5SLC18A3HTR2CPRCP | |
| SCHEMBL8203121 | 0.82 | DRD3 (0.43) | SLC18A3HTR2CCARM1PRMT6DRD2 | |
| SCHEMBL8203423 | 0.82 | DRD3 (0.43) | SLC18A3HTR2CHTR7SIGMAR1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |