SCHEMBL8203447

SCHEMBL8203447

O=S(=O)(O)c1ccc(CCCc2ccc(P(Cc3ccccc3-c3ccccc3CP(c3ccc(CCCc4ccc(S(=O)(=O)O)cc4)cc3)c3ccc(CCCc4ccc(S(=O)(=O)O)cc4)cc3)c3ccc(CCCc4ccc(S(=O)(=O)O)cc4)cc3)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.36
TSHR P16473 2/20 0.36
CA2 P00918 8/20 0.35
CA1 P00915 3/20 0.33
CA9 Q16790 3/20 0.33
CA12 O43570 2/20 0.33
POLB P06746 1/20 0.33
CYP2D6 P10635 1/20 0.33
CA4 P22748 1/20 0.33
TYMS P04818 1/20 0.32
HTR6 P50406 1/20 0.32
LMNA P02545 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
FDFT1 P37268 1/20 0.31
ALDH1A1 P00352 1/20 0.31
NT5E P21589 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8201619 0.82 HTR2A (0.44) SMN1; SMN2HDAC1HDAC8
SCHEMBL28276274 0.76 SMN1; SMN2 (0.58) SMN1; SMN2TSHRCA2CA1CA12
SCHEMBL10683133 0.75 TSHR (0.52) SMN1; SMN2TSHRCA2CA1CA9
SCHEMBL1313179 0.74 ALDH1A1 (0.41) SMN1; SMN2TSHRPOLBCYP2D6TYMS
Ammonia Solution, Strong SCHEMBL3010015 0.73 TSHR (0.40) SMN1; SMN2TSHRTYMSALDH1A1
SCHEMBL27262694 0.73 TSHR (0.50) SMN1; SMN2TSHRCA2CA1CA9
SCHEMBL8723203 0.73 CA2 (0.50) SMN1; SMN2TSHRCA2CA1CA9
SCHEMBL21111342 0.72 SMN1; SMN2 (0.58) SMN1; SMN2TSHRCA2POLBCYP2D6
SCHEMBL30446884 0.72 CA2 (0.57) SMN1; SMN2TSHRCA2CA1CA9
SCHEMBL29695439 0.70 CYP3A4 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043398-A WATER-SOLUBLE, SULFONATED DIPHOSPHINES COMPLEXED WITH A TRANSITION METAL TO FORM HYDROFORMYLATION CATALYSTS; OUTSTANDING SURFACE ACTIVE PROPERTIES IN TWO PHASE CATALYSIS OF TWO PHASE HYDROFORMYLATION OF OCT-1-ENE OLEFINS CELANESE INTERNATIONAL CORPORATION (US) 2000-03-28 US disclosed
EP-0898573-A1 ARYL DIPHOSPHINES AND CATALYSTS CONTAINING THE SAME Hoechst Celanese Corporation (US) 1999-03-03 EP disclosed
WO-1997039005-A1 ARYL DIPHOSPHINES AND CATALYSTS CONTAINING THE SAME HOECHST CELANESE CORPORATION (US) 1997-10-23 WO disclosed