Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA6 | P23280 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10824823 | 0.95 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL4347324 | 0.82 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL14479079 | 0.78 | HMGCR (0.41) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL19283269 | 0.78 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL6857749 | 0.77 | NLRP3 (0.36) | NPC1RAB9ASMN1; SMN2LMNANLRP3 | |
| SCHEMBL8021615 | 0.77 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL8020977 | 0.77 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL8026467 | 0.77 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL18014854 | 0.77 | HCAR2 (0.39) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL18014878 | 0.77 | HCAR2 (0.43) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-7183293-B2 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. (US) | 2007-02-27 | — | — | US | disclosed |
| CN-1268937-A | Novel compound having effect of promoting neuron differentiation | NIPPON KAYAKU KK (JP) | 2000-10-04 | — | — | CN | disclosed |
| EP-0999204-A1 | NOVEL COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-05-10 | — | — | EP | disclosed |
| CN-1210515-A | 2,3-disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof | NIPPON KAYAKU KK (JP) | 1999-03-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PDE4A, PDE4B, PDE4D | NPC1 3069/4885RAB9A 993/4885SMN1; SMN2 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.