Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693248 | 0.81 | FPR2 (0.44) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL11625004 | 0.81 | KDM4E (0.45) | ADRA2AADRA2BADRA2CCYP3A4CSNK1A1 | |
| SCHEMBL10612552 | 0.81 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL570524 | 0.79 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL7649635 | 0.78 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| Hydrochloric Acid SCHEMBL28220351 | 0.78 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| Bromide SCHEMBL28219788 | 0.78 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL8207306 | 0.76 | ALDH1A1 (0.45) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL6448258 | 0.75 | FPR2 (0.43) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 | |
| SCHEMBL28626525 | 0.75 | FPR2 (0.43) | ADRA2AADRA2BADRA2CCSNK1A1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |