SCHEMBL8205885

SCHEMBL8205885

CC1=C(C)OC(O)(c2ccccc2)N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.37
SLC6A2 P23975 2/20 0.37
CHRNB4 P30926 2/20 0.37
CHRNA3 P32297 2/20 0.37
CHRNA4 P43681 2/20 0.37
SLC6A3 Q01959 1/20 0.37
OPRM1 P35372 5/20 0.34
OPRK1 P41145 4/20 0.34
OPRL1 P41146 3/20 0.34
ADAM17 P78536 1/20 0.31
CYP1A2 P05177 2/20 0.31
HCAR3 P49019 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31
ALDH1A1 P00352 1/20 0.30
OPRD1 P41143 1/20 0.30
CHRNA1 P02708 1/20 0.30
CHRNG P07510 1/20 0.30
CHRNB1 P11230 1/20 0.30
CHRND Q07001 1/20 0.30
F2 P00734 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8205801 0.81 CHRNB2 (0.35) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL7607324 0.69 ALOX5 (0.39) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL15524924 0.68 OPRM1 (0.38) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL15337519 0.63 CNR1 (0.36) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL27697611 0.60 CHRNB2 (0.33) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL2903897 0.60 HDAC1 (0.35) OPRM1OPRK1OPRL1NPC1
SCHEMBL10339222 0.57 HDAC1 (0.38) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL10641415 0.56 CYP1A2 (0.39) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL10641412 0.56 CYP1A2 (0.39) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL10641405 0.56 CYP1A2 (0.39) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6096144-A TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2000-08-01 US disclosed
US-5858571-A TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-01-12 US disclosed
EP-0172427-B1 PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER Shin-Etsu Chemical Co., Ltd. (JP) 1989-07-05 EP disclosed
US-4758639-A Process for production of vinyl polymer SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-19 US disclosed
US-4757124-A Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-12 US disclosed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP disclosed