Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273539 | 0.88 | GAA (0.43) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8205834 | 0.88 | GAA (0.42) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8209175 | 0.82 | CA2 (0.41) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8213603 | 0.81 | HTR2B (0.40) | GAASMN1; SMN2KDM4EALDH1A1HTR2B | |
| SCHEMBL8205467 | 0.81 | NAMPT (0.40) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8198280 | 0.81 | FNTA (0.46) | ALDH1A1 | |
| SCHEMBL8206389 | 0.81 | FNTA (0.46) | ALDH1A1 | |
| SCHEMBL8205943 | 0.81 | ERAP2 (0.40) | GAASMN1; SMN2NAMPT | |
| SCHEMBL8209367 | 0.81 | GAA (0.39) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8206480 | 0.81 | NR4A2 (0.37) | ALDH1A1NR4A2UNGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |