Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206086 | 0.88 | GAA (0.43) | GAASMN1; SMN2ALDH1A1KDM4EHTR2B | |
| SCHEMBL8212307 | 0.86 | ALDH1A1 (0.47) | GAASMN1; SMN2ALDH1A1KDM4EHTR2B | |
| SCHEMBL8213603 | 0.84 | HTR2B (0.40) | GAASMN1; SMN2ALDH1A1KDM4EHTR2B | |
| SCHEMBL4642176 | 0.83 | NAMPT (0.37) | KDM4EHTR2BNAMPT | |
| SCHEMBL8204858 | 0.81 | GAA (0.36) | GAASMN1; SMN2ALDH1A1KDM4EHTR2B | |
| SCHEMBL8205624 | 0.79 | CA2 (0.46) | GAASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL8273539 | 0.77 | GAA (0.43) | GAASMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL5093427 | 0.76 | RAB9A (0.53) | GAASMN1; SMN2ALDH1A1KDM4EHTR2B | |
| SCHEMBL8206519 | 0.75 | NAMPT (0.38) | NAMPT | |
| SCHEMBL8205928 | 0.74 | NAMPT (0.39) | GAASMN1; SMN2ALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |