Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212886 | 0.91 | HPGD (0.58) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8200310 | 0.89 | HPGD (0.56) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8209522 | 0.87 | TDP1 (0.60) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8211804 | 0.85 | LMNA (0.66) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8199868 | 0.84 | MEN1 (0.56) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL7888362 | 0.82 | SMN1; SMN2 (0.61) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL20828646 | 0.80 | HPGD (0.73) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8199058 | 0.80 | THRB (0.52) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL8207751 | 0.79 | TDP1 (0.56) | HPGDMEN1KMT2AALDH1A1PKM | |
| SCHEMBL8206773 | 0.79 | CYP3A4 (0.53) | HPGDMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |