Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8975966 | 0.81 | ALDH1A1 (0.41) | LMNASMN1; SMN2TSHRSLC6A4SLC6A2 | |
| SCHEMBL11851873 | 0.78 | LMNA (0.42) | LMNASMN1; SMN2TSHRHPGDSLC6A4 | |
| SCHEMBL54888 | 0.78 | LMNA (0.47) | LMNASMN1; SMN2TSHRHPGDSLC6A4 | |
| SCHEMBL8975977 | 0.76 | LMNA (0.41) | LMNASMN1; SMN2TSHRHPGDSLC6A4 | |
| SCHEMBL9329848 | 0.75 | HPGD (0.47) | LMNATSHRHPGDL3MBTL1SLC6A2 | |
| SCHEMBL18660553 | 0.75 | TP53 (0.42) | LMNATSHRHPGDSLC6A2SLC6A3 | |
| SCHEMBL6219566 | 0.73 | L3MBTL1 (0.38) | L3MBTL1SLC6A2SLC6A3ALDH1A1MEN1 | |
| SCHEMBL7558433 | 0.73 | HTR7 (0.38) | LMNASMN1; SMN2HPGDL3MBTL1ALDH1A1 | |
| SCHEMBL8975558 | 0.73 | TSHR (0.43) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL6221752 | 0.73 | CA1 (0.62) | LMNASMN1; SMN2TSHRHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759929-B1 | OXIDATION OF STEROIDS HAVING ALLYLIC GROUPS | MERCK & CO INC (US) | 2000-08-23 | — | — | EP | claimed |
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |