Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2629285 | 0.83 | KCNH2 (0.45) | KCNH2GPR119ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL240638 | 0.81 | SMN1; SMN2 (0.47) | KCNH2GPR119ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL81828 | 0.79 | HTR3A (0.52) | KCNH2GPR119HTR3AHRH4RAB9A | |
| SCHEMBL19145233 | 0.79 | SLC6A9 (0.44) | KCNH2GPR119SLC6A9ALDH1A1KDM4E | |
| SCHEMBL807298 | 0.78 | ALDH1A1 (0.54) | HRH4ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL2629281 | 0.78 | PLD1 (0.47) | KCNH2GPR119HRH4ALDH1A1HPGD | |
| SCHEMBL26340620 | 0.78 | KCNH2 (0.42) | KCNH2GPR119HTR3AHRH4SLC6A9 | |
| SCHEMBL2000301 | 0.76 | GRIN2D (0.53) | GPR119ALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL1713165 | 0.76 | HRH4 (0.41) | HTR3AHRH4ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20180620 | 0.76 | KCNH2 (0.41) | KCNH2GPR119CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110939-A | AS A SUBSTANCE P ANTAGONISTS TREATING TACHYKININ-MEDIATED DISEASE, ASTHMA, CENTRAL NERVOUS SYSTEM DISORDER | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-29 | — | — | US | disclosed |