SCHEMBL8207397

SCHEMBL8207397

O=C(O)C(=Cc1ccccc1)C(=O)O[SiH3]

nearest known ligand 0.67

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
HTT P42858 1/20 0.51
AKR1C3 P42330 1/20 0.47
AKR1C1 Q04828 1/20 0.46
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
NR1H4 Q96RI1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7607207 0.82 TP53 (0.55) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL4972255 0.81 TP53 (0.68) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL4972259 0.81 TP53 (0.68) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL29898330 0.81 TP53 (0.75) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL39098 0.81 TP53 (0.75) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL6005632 0.81 MEN1 (0.58) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL11501360 0.81 TP53 (0.53) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL433479 0.81 TP53 (0.53) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL9333655 0.81 HTT (0.56) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL3430755 0.81 MEN1 (0.58) TP53MEN1KMT2AHTTAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-10324620-A None JP disclosed
JP-10324620-A None JP disclosed
JP-2000136120-A METHOD FOR IMPROVING LIGHT STABILITY OF DIBENZOYLMETHANE DERIVATIVE WITH BENZAL MALONATE SILANE AND LIGHT STABILITY IMPROVING AGENT L'OREAL SA 2000-05-16 JP disclosed
JP-2000136120-A METHOD FOR IMPROVING LIGHT STABILITY OF DIBENZOYLMETHANE DERIVATIVE WITH BENZAL MALONATE SILANE AND LIGHT STABILITY IMPROVING AGENT L'OREAL SA 2000-05-16 JP disclosed
JP-H10324620-A IMPROVEMENT FOR PHOTOSTABILIZATION OF BENZOYLMETHANE DERIVATIVE BY BENZAL MALONATE SILANE AND PRODUCTION OF BENZAL MALONATE SILANE L'OREAL SA 1998-12-08 JP disclosed
JP-H10324620-A IMPROVEMENT FOR PHOTOSTABILIZATION OF BENZOYLMETHANE DERIVATIVE BY BENZAL MALONATE SILANE AND PRODUCTION OF BENZAL MALONATE SILANE L'OREAL SA 1998-12-08 JP disclosed