SCHEMBL7607207

SCHEMBL7607207

O=C(O)C(=Cc1ccccc1)C(=O)OO

nearest known ligand 0.69

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
HTT P42858 1/20 0.53
AKR1C3 P42330 1/20 0.48
AKR1C1 Q04828 1/20 0.47
CYP2C9 P11712 2/20 0.43
CYP3A4 P08684 1/20 0.43
LMNA P02545 1/20 0.42
CYP1A2 P05177 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C19 P33261 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
NR1H4 Q96RI1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4972259 0.83 TP53 (0.68) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL4972255 0.83 TP53 (0.68) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL29898330 0.83 TP53 (0.75) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL39098 0.83 TP53 (0.75) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL6005632 0.82 MEN1 (0.58) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL11501360 0.82 TP53 (0.53) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL8207397 0.82 TP53 (0.53) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL9333655 0.82 HTT (0.56) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL3430755 0.82 MEN1 (0.58) TP53MEN1KMT2AHTTAKR1C3
SCHEMBL433479 0.82 TP53 (0.53) TP53MEN1KMT2AHTTAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020016488-A1 UV-PHOTOPROTECTIVE DIBENZOYLMETHANE COMPOSITIONS COMPRISING PHOTOSTABILIZING AMOUNTS OF BENZALMALONATE SILANES FORESTIER SERGE (FR) 2002-02-07 US claimed
EP-0868905-A2 Method for enhancing the photostability of a dibenzoylmethane derivate with a silane benzalmalonate and method of preparation of silane bezalmalonates L'OREAL (FR) 1998-10-07 EP claimed
US-6426428-B2 SUNSCREENS/COSMETICS USED ON HUMAN HAIR AND/OR SKING Societe L′Oreal (FR) 2002-07-30 US disclosed
US-20020016488-A1 UV-PHOTOPROTECTIVE DIBENZOYLMETHANE COMPOSITIONS COMPRISING PHOTOSTABILIZING AMOUNTS OF BENZALMALONATE SILANES FORESTIER SERGE (FR) 2002-02-07 US disclosed
US-5951968-A UV-photoprotective dibenzoylmethane compositions comprising photostabilizing amounts of benzalmalonate silanes SOCIETE L'OREAL S.A. (FR) 1999-09-14 US disclosed
EP-0868905-A2 Method for enhancing the photostability of a dibenzoylmethane derivate with a silane benzalmalonate and method of preparation of silane bezalmalonates L'OREAL (FR) 1998-10-07 EP disclosed
US-3943094-A Polymers and copolymers based on alkenoyl-oxybenzylidene-malonic esters as UV-absorbers and polymers stabilized therewith BAYER AKTIENGESELLSCHAFT (DT) 1976-03-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020016488-A1 UV-PHOTOPROTECTIVE DIBENZOYLMETHANE COMPOSITIONS COMPRISING PHOTOSTABILIZING AMOUNTS OF BENZALMALONATE SILANES TST, TMT1A, TBCA TP53 589/4885MEN1 1420/4885KMT2A 2057/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.