SCHEMBL8207458

SCHEMBL8207458

CCCCCCCCCCCCCCCCCCOC(CC)c1nc(N)c2nc[nH]c2n1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 3/20 0.40
CCNB1 P14635 3/20 0.40
CCNA2 P20248 2/20 0.38
CDK2 P24941 2/20 0.38
CCNA1 P78396 2/20 0.38
NOS1 P29475 1/20 0.36
PIN1 Q13526 1/20 0.34
XDH P47989 2/20 0.33
MCHR1 Q99705 2/20 0.33
TLR8 Q9NR97 2/20 0.33
DNM1 Q05193 1/20 0.31
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6897931 0.78 CDK1 (0.46) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL8215833 0.78 NOS1 (0.38) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL8219211 0.78 NOS1 (0.38) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL3878324 0.78 CYP3A4 (0.35)
SCHEMBL516302 0.78 ADORA2A (0.39) CDK1CCNB1ALDH1A1
SCHEMBL8252218 0.76 XDH (0.33) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6036797 0.76 CDK1 (0.34) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL67129 0.74 CDK1 (0.31) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL4364337 0.73 CDK1 (0.36) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL1146060 0.72 CDK1 (0.43) CDK1CCNB1CCNA2CDK2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000059906-A1 AMINOHETEROCYCLE-SUBSTITUTED GLYCEROLS CLARION PHARMACEUTICALS, INC. (US) 2000-10-12 WO disclosed