SCHEMBL67129

SCHEMBL67129

CCC(N)c1nc(N)c2nc[nH]c2n1

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 2/20 0.31
CCNB1 P14635 2/20 0.31
CCNA2 P20248 2/20 0.31
CDK2 P24941 2/20 0.31
CCNA1 P78396 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6036797 0.84 CDK1 (0.34) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL11801311 0.82 ADORA2A (0.31) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6009519 0.80 ADORA2A (0.38) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL13269040 0.79 TLR8 (0.34)
SCHEMBL13268707 0.79 TLR8 (0.34)
SCHEMBL4364337 0.78 CDK1 (0.36) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6267281 0.78 USP2 (0.30)
SCHEMBL16103450 0.76 QPCT (0.35)
SCHEMBL7165315 0.75 CDK1 (0.31) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL669639 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1996 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013071079-A1 LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULAR PROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2013-05-16 WO claimed
WO-2026106956-A1 DISULFIDE-STABILIZED NOROVIRUS VIRUS-LIKE PARTICLE DESIGN MERCK SHARP & DOHME LLC (US) 2026-05-21 WO disclosed
US-20260138999-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS BRISTOL MYERS SQUIBB CO (US) 2026-05-21 US disclosed
US-12629412-B2 Betacoronavirus mRNA vaccines MODERNATX, INC. (US) 2026-05-19 US disclosed
WO-2026102123-A1 SEQUENCE CAPTURE TECHNOLOGY AND PROBE DESIGN MONSANTO TECHNOLOGY LLC (US) 2026-05-15 WO disclosed
WO-2026098737-A1 NUCLEIC ACID CONJUGATE AND PHARMACEUTICAL COMPOSITION FOR LIPID DELIVERY, AND USE THEREOF 苏州时安生物技术有限公司 2026-05-15 WO disclosed
US-20260130985-A1 NUCLEIC ACID-BASED UNIVERSAL VACCINE AND METHODS OF USE THEREOF ADVANCED RNA VACCINE ARV TECH INC (US) 2026-05-14 US disclosed
US-20260132405-A1 Modulation of Apolipoprotein C-III (ApoCIII) Expression in Lipoprotein Lipase Deficient (LPLD) Populations IONIS PHARMACEUTICALS, INC. (US) 2026-05-14 US disclosed
US-12622960-B2 Varicella zoster virus (VZV) vaccine MODERNATX, INC. (US) 2026-05-12 US disclosed
US-20260108595-A1 BETACORONAVIRUS mRNA VACCINES MODERNATX, INC. (US) 2026-04-23 US disclosed
US-20050221275-A1 Hepatocyte free uptake assays ISIS PHARMACEUTICALS, INC. 2005-10-06 US disclosed
EP-1560840-A2 COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION Isis Pharmaceuticals, Inc. (US) 2005-08-10 EP disclosed
US-20050164209-A1 Hepatocyte free uptake assays ISIS PHARMACEUTICALS, INC. 2005-07-28 US disclosed
US-20050080246-A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation IONIS PHARMACEUTICALS, INC. 2005-04-14 US disclosed
WO-2005013901-A2 OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN MODULATION OF SMALL NON-CODING RNAS ISIS PHARMACEUTICALS, INC. (US) 2005-02-17 WO disclosed
US-20050026160-A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation IONIS PHARMACEUTICALS, INC. 2005-02-03 US disclosed
WO-2004044136-A2 COMPOSITIONS COMPRISING ALTERNATING 2’-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION ISIS PHARMACEUTICALS, INC. (US) 2004-05-27 WO disclosed
WO-2003008550-A2 SYNTHESIS OF OLIGONUCLEOTIDES ON SOLID SUPPORTS INCLUDING NON-REACTIVE SOLID DILUENTS ISIS PHARMACEUTICALS, INC. (US) 2003-01-30 WO disclosed
EP-1137658-A1 METHODS OF MODULATING TUMOR NECROSIS FACTOR $g(a)-INDUCED EXPRESSION OF CELL ADHESION MOLECULES ISIS PHARMACEUTICALS, INC. (US) 2001-10-04 EP disclosed
WO-2000034303-A1 METHODS OF MODULATING TUMOR NECROSIS FACTOR α-INDUCED EXPRESSION OF CELL ADHESION MOLECULES ISIS PHARMACEUTICALS, INC. (US) 2000-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050080246-A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation NSUN2, RNMT, NSUN3 CDK1 3493/4885CCNB1 2772/4885CCNA2 899/4885
US-20260138999-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS RNGTT, CDA, DCTD CDK1 1534/4885CCNB1 790/4885CCNA2 768/4885
US-12629412-B2 Betacoronavirus mRNA vaccines RNMT, RNGTT, METTL16 CDK1 4464/4885CCNB1 3763/4885CCNA2 3037/4885
US-20260108595-A1 BETACORONAVIRUS mRNA VACCINES RNMT, METTL16, NSUN2 CDK1 4626/4885CCNB1 3460/4885CCNA2 3719/4885
US-12622960-B2 Varicella zoster virus (VZV) vaccine NSUN2, RNMT, RNGTT CDK1 3011/4885CCNB1 1626/4885CCNA2 1994/4885
US-20050026160-A1 Compositions comprising alternating 2'-modified nucleosides for use in gene modulation NSUN2, RNMT, NSUN3 CDK1 3493/4885CCNB1 2772/4885CCNA2 899/4885
US-20260132405-A1 Modulation of Apolipoprotein C-III (ApoCIII) Expression in Lipoprotein Lipase Deficient (LPLD) Populations LPL, APOL1, PNLIP CDK1 4503/4885CCNB1 3894/4885CCNA2 4647/4885
US-20260130985-A1 NUCLEIC ACID-BASED UNIVERSAL VACCINE AND METHODS OF USE THEREOF UPF1, NSUN2, CD4 CDK1 3896/4885CCNB1 3735/4885CCNA2 2632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.