Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 17/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 16/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 13/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209134 | 0.96 | MAPK8 (0.59) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8212037 | 0.91 | MAPK8 (0.51) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL12853363 | 0.91 | MAPK8 (0.52) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8213930 | 0.89 | MAPK8 (0.49) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL12853349 | 0.89 | MAPK8 (0.51) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8200906 | 0.87 | HPGD (0.54) | CA1CA2EPHX2NR1H4 | |
| SCHEMBL8209109 | 0.86 | CA2 (0.74) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8207782 | 0.85 | CA1 (0.49) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL8213923 | 0.84 | ALDH1A1 (0.49) | MAPK8MAPK9MAPK10CA1CA2 | |
| SCHEMBL12853369 | 0.82 | XDH (0.49) | MAPK8MAPK9MAPK10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |
| US-8278337-B2 | Substituted pyridines that are JNK inhibitors | MERCK SHARP & DOHME (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278337-B2 | Substituted pyridines that are JNK inhibitors | MERCK SHARP & DOHME (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100179141-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100179141-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-07-15 | — | — | US | disclosed |
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179141-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK5, MAPK15 | MAPK8 13/4885MAPK9 11/4885MAPK10 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.