Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421194 | 0.93 | LMNA (0.45) | LMNAHPGDGAAREV1PDE5A | |
| SCHEMBL8207861 | 0.92 | LMNA (0.46) | LMNAHPGDGAAPDE5ANPC1 | |
| SCHEMBL8206305 | 0.92 | NPC1 (0.48) | LMNAGAAREV1NPC1PKM | |
| Bicarbonate SCHEMBL7421198 | 0.90 | TSHR (0.44) | LMNAHPGDGAAREV1PDE5A | |
| SCHEMBL8199034 | 0.90 | GAA (0.50) | LMNAHPGDGAAREV1PDE5A | |
| SCHEMBL8207774 | 0.85 | LMNA (0.47) | LMNAHPGDNPC1PKMRAB9A | |
| SCHEMBL7889431 | 0.85 | LMNA (0.46) | LMNAHPGDGAAPDE5ANPC1 | |
| SCHEMBL7886925 | 0.84 | POLB (0.52) | LMNAREV1NPC1PKMRAB9A | |
| SCHEMBL8206616 | 0.84 | GAA (0.49) | LMNAHPGDGAAREV1PDE5A | |
| SCHEMBL8250085 | 0.84 | REV1 (0.45) | LMNAGAAREV1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |