Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207861 | 0.94 | LMNA (0.46) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL7881446 | 0.93 | NPC1 (0.49) | LMNANPC1PKMRAB9AKMT2A | |
| Bicarbonate SCHEMBL7881448 | 0.90 | KMT2A (0.46) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL8206305 | 0.90 | NPC1 (0.48) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL8206662 | 0.89 | GAA (0.53) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL8207562 | 0.87 | ALDH1A1 (0.43) | LMNARAB9AKMT2APOLBALDH1A1 | |
| SCHEMBL8207740 | 0.87 | HPGD (0.42) | LMNANPC1PKMRAB9AHPGD | |
| SCHEMBL7889431 | 0.86 | LMNA (0.46) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL8207597 | 0.85 | LMNA (0.45) | LMNANPC1PKMRAB9AKMT2A | |
| SCHEMBL8199034 | 0.85 | GAA (0.50) | LMNANPC1PKMRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |