Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207562 | 0.90 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBGAAHIF1A | |
| SCHEMBL8199985 | 0.90 | NPC1 (0.46) | TP53ALDH1A1MAPTPOLBGAA | |
| SCHEMBL7892994 | 0.90 | USP2 (0.45) | HPGDTP53USP2ALDH1A1HSD11B1 | |
| SCHEMBL8207368 | 0.89 | REV1 (0.47) | HPGDGLATP53USP2ALDH1A1 | |
| SCHEMBL8212725 | 0.88 | GAA (0.56) | HPGDGLATP53USP2ALDH1A1 | |
| SCHEMBL8207845 | 0.87 | AKR1B1 (0.47) | HPGDTP53ALDH1A1MAPTPOLB | |
| Bicarbonate SCHEMBL7892996 | 0.87 | HPGD (0.50) | HPGDTP53USP2ALDH1A1MAPT | |
| SCHEMBL8207774 | 0.87 | LMNA (0.47) | HPGDALDH1A1POLBNPC1PKM | |
| SCHEMBL8207861 | 0.86 | LMNA (0.46) | HPGDGAANPC1PKMRAB9A | |
| SCHEMBL8211919 | 0.84 | KDM4E (0.54) | HPGDMAPTPOLBGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |