Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 7/20 | 0.39 |
| ▸ | DRD3 | P35462 | 7/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208107 | 0.87 | HRH1 (0.40) | DRD1DRD3CHRM2CHRM1ADRA2A | |
| SCHEMBL8208376 | 0.86 | HRH1 (0.37) | HTR2CHRH1LMNAHRH4HTT | |
| SCHEMBL8200919 | 0.85 | CYP1A2 (0.33) | DRD3CYP2D6CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL8207652 | 0.83 | HRH1 (0.45) | CHRM2HTR2AHRH1KCNH2LMNA | |
| SCHEMBL7139912 | 0.80 | HRH1 (0.44) | DRD1DRD3CHRM2CHRM1ADRA2A | |
| SCHEMBL8211235 | 0.79 | HTR5A (0.46) | DRD1DRD3HTR2AHRH1LMNA | |
| Oxalic Acid SCHEMBL9280234 | 0.77 | SIGMAR1 (0.40) | HTR2AKCNH2LMNAOPRM1MAPT | |
| SCHEMBL7136207 | 0.76 | SETD7 (0.59) | DRD1DRD3CHRM2CHRM1ADRA2A | |
| SCHEMBL7174262 | 0.72 | PTAFR (0.43) | CHRM2CHRM1HTR2AHTR2CHRH1 | |
| SCHEMBL7140008 | 0.72 | DRD2 (0.43) | DRD1DRD3CHRM2CHRM1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675889-B1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-07-05 | — | — | EP | claimed |
| US-5595988-A | Triazolo(pyrrolo, thieno or furano)azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-01-21 | — | — | US | claimed |
| EP-0675889-B1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-07-05 | — | — | EP | disclosed |
| US-5595988-A | Triazolo(pyrrolo, thieno or furano)azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-01-21 | — | — | US | disclosed |