Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8207791 | 0.86 | DRD1 (0.39) | HRH1HRH4HTR2CLMNAHTT | |
| SCHEMBL8208107 | 0.81 | HRH1 (0.40) | HRH1HRH4HTR2CLMNA | |
| SCHEMBL7138901 | 0.80 | HRH1 (0.54) | HRH1HRH4HTR2CPNMTJAK2 | |
| SCHEMBL8207652 | 0.78 | HRH1 (0.45) | HRH1LMNANOS3NOS2 | |
| SCHEMBL8200919 | 0.77 | CYP1A2 (0.33) | JAK2 | |
| SCHEMBL8211235 | 0.74 | HTR5A (0.46) | HRH1LMNAHTT | |
| SCHEMBL7141253 | 0.73 | PTAFR (0.38) | HRH1HRH4HTR2CLMNA | |
| SCHEMBL7138938 | 0.73 | HRH1 (0.42) | HRH1HRH4HTR2CPNMTLMNA | |
| Oxalic Acid SCHEMBL9280234 | 0.70 | SIGMAR1 (0.40) | LMNAHTT | |
| SCHEMBL8207088 | 0.69 | HRH1 (0.69) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675889-B1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-07-05 | — | — | EP | disclosed |
| US-5595988-A | Triazolo(pyrrolo, thieno or furano)azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-01-21 | — | — | US | disclosed |