Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7888439 | 0.91 | GRIN2C (0.57) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8206984 | 0.90 | ALDH1A1 (0.54) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8207961 | 0.88 | MGLL (0.53) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8199930 | 0.87 | MGLL (0.52) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7889265 | 0.80 | GRIN2C (0.60) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8207045 | 0.80 | ALDH1A1 (0.53) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8207525 | 0.79 | GAA (0.54) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8207378 | 0.79 | ALDH1A1 (0.48) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7272416 | 0.78 | MGLL (0.74) | MAPTRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8206929 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |