Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208544 | 0.93 | HTR6 (0.44) | HTR6HTR1A | |
| SCHEMBL8201465 | 0.92 | HTR6 (0.43) | HTR6HTR2A | |
| SCHEMBL8201582 | 0.87 | HTR6 (0.50) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL8201576 | 0.85 | HTR6 (0.63) | HTR6 | |
| SCHEMBL8209083 | 0.81 | PDE4B (0.38) | HTR6PDE4BPDE4D | |
| SCHEMBL8201606 | 0.80 | HTR6 (0.45) | HTR6HTR1AHTR2A | |
| SCHEMBL8209777 | 0.78 | HTR6 (0.53) | HTR6HTR1AHTR2A | |
| SCHEMBL8209795 | 0.77 | HTR6 (0.49) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL7472995 | 0.77 | HTR6 (0.48) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL8208598 | 0.76 | HTR6 (0.48) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |