Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Protizinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CDC42 | P60953 | 1/20 | 0.44 |
| ▸ | RAC1 | P63000 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Protizinic Acid SCHEMBL29359535 | 0.89 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| Protizinic Acid SCHEMBL18309842 | 0.89 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| Protizinic Acid SCHEMBL25022 | 0.89 | AKR1C3 (0.54) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| Naproxen SCHEMBL27586482 | 0.78 | AKR1C3 (0.72) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| Naproxen SCHEMBL2038673 | 0.78 | AKR1C3 (0.72) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| SCHEMBL10618628 | 0.78 | NOX1 (0.58) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| SCHEMBL2739325 | 0.76 | SNCA (0.59) | PTGS1CYP1A2KDM4ETP53MAPK1 | |
| Protizinic Acid SCHEMBL2072946 | 0.73 | PTGS1 (0.63) | AKR1C3AKR1C2PTGS2PTGS1CYP1A2 | |
| SCHEMBL11255517 | 0.73 | SNCA (0.53) | PTGS1CYP1A2KDM4ETP53MAPK1 | |
| Rosmarinic Acid SCHEMBL9446582 | 0.72 | MMP1 (0.56) | CYP1A2KDM4ESNCAHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977725-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998032718-A1 | NEW FATTY ACID DERIVATIVES | NORSK HYDRO ASA (NO) | 1998-07-30 | — | — | WO | disclosed |