Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 14/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4404845 | 0.83 | KCNA3 (0.50) | LTA4HCYP2C9CYP2C19LMNA | |
| SCHEMBL9450788 | 0.81 | LTA4H (0.55) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10599543 | 0.75 | LMNA (0.69) | LTA4HL3MBTL1CYP1A2CYP2C19LMNA | |
| SCHEMBL8672820 | 0.75 | LTA4H (0.74) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL11856925 | 0.75 | LMNA (0.69) | LTA4HL3MBTL1CYP1A2CYP2C19LMNA | |
| SCHEMBL3039068 | 0.74 | LTA4H (0.67) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2091073 | 0.74 | LTA4H (0.60) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10062561 | 0.74 | LTA4H (0.63) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1912758 | 0.74 | LTA4H (0.71) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29127296 | 0.74 | LTA4H (0.60) | LTA4HL3MBTL1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971909-A1 | LTA 4? HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998040370-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | disclosed |