Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | REN | P00797 | 11/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | CTSE | P14091 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13592480 | 1.00 | CTSK (0.47) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL8211616 | 1.00 | CTSK (0.47) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL7860632 | 1.00 | CTSK (0.47) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL13592481 | 1.00 | CTSK (0.47) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL27076694 | 0.94 | CTSK (0.49) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL9831856 | 0.88 | CTSS (0.50) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL2809379 | 0.88 | CTSK (0.51) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL13347448 | 0.88 | CTSK (0.48) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL13347447 | 0.88 | CTSK (0.48) | CTSKCTSSRENCA1CA2 | |
| SCHEMBL12161411 | 0.88 | CTSK (0.51) | CTSKCTSSRENCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113821-A1 | PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE | SCHERING-PLOUGH CORPORATION (US) | 2010-05-06 | — | — | US | disclosed |
| US-20090312576-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF | SCHERING CORPORATION | 2009-12-17 | — | — | US | disclosed |
| US-20090312576-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF | SCHERING CORPORATION | 2009-12-17 | — | — | US | disclosed |
| US-7595419-B2 | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof | SCHERING CORPORATION (US) | 2009-09-29 | — | — | US | disclosed |
| US-7595419-B2 | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof | SCHERING CORPORATION (US) | 2009-09-29 | — | — | US | disclosed |
| WO-2008082486-A2 | PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312576-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 3-(AMINO)-3-CYCLOBUTYLMETHYL-2-HYDROXY-PROPIONAMIDE OR SALTS THEREOF | PCCA, IDH3A, ALDH18A1 | CTSK 3678/4885CTSS 2837/4885REN 99/4885 |
| US-20100113821-A1 | PREPARATION OF 3-AMINO-3-(CYCLOBUTYLMETHYL)-2-(HYDROXY)-PROPIONAMIDE HYDROCHLORIDE | CTRL, DNPEP, DPP3 | CTSK 319/4885CTSS 42/4885REN 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.