Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208262 | 0.87 | CHRM4 (0.47) | ALDH1A1LMNAPOLBHPGDSMN1; SMN2 | |
| SCHEMBL12853613 | 0.87 | USP30 (0.51) | ACACBUSP30DRD3F10 | |
| SCHEMBL8208875 | 0.82 | LMNA (0.48) | ACACBALDH1A1LMNAPOLBHPGD | |
| SCHEMBL8201048 | 0.82 | USP30 (0.47) | ACACBUSP30ALDH1A1LMNAPOLB | |
| SCHEMBL8206262 | 0.77 | KDM4E (0.64) | — | |
| SCHEMBL8206269 | 0.73 | ADRB2 (0.45) | ALDH1A1POLBHPGDMAPK14 | |
| SCHEMBL8198448 | 0.73 | KDM4E (0.56) | — | |
| SCHEMBL8211821 | 0.70 | ROCK2 (0.47) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8205739 | 0.70 | FAAH (0.37) | ACACBLMNA | |
| SCHEMBL8207800 | 0.70 | ROCK2 (0.47) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |