Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30744539 | 0.87 | PPARD (0.42) | KLKB1KDM4EALDH1A1HSD17B10PPARD | |
| SCHEMBL21493002 | 0.87 | PPARD (0.42) | KLKB1KDM4EALDH1A1HSD17B10PPARD | |
| SCHEMBL27286166 | 0.83 | KDM4E (0.49) | KLKB1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL17685622 | 0.82 | KLKB1 (0.46) | KLKB1KDM4EALDH1A1HSD17B10LMNA | |
| SCHEMBL28532124 | 0.81 | PPARD (0.39) | KLKB1KDM4EALDH1A1HSD17B10PPARD | |
| SCHEMBL21491889 | 0.79 | KLKB1 (0.44) | KLKB1PPARD | |
| SCHEMBL21503682 | 0.79 | LOXL2 (0.40) | KLKB1PPARDLMNAKCNH2MAPT | |
| Hydrochloric Acid SCHEMBL21491894 | 0.77 | LMNA (0.41) | KLKB1PPARDLMNAKCNH2MAPT | |
| Hydrochloric Acid SCHEMBL30744436 | 0.77 | LMNA (0.41) | KLKB1PPARDLMNAKCNH2MAPT | |
| SCHEMBL25269987 | 0.77 | GRIN1 (0.40) | PPARDLMNAKCNH2GPR119MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188099-B2 | Method of decreasing hepatotoxic side effects using A2B adenosine receptor antagonists | GILEAD SCIENCES, INC. (US) | 2012-05-29 | — | — | US | disclosed |