Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395422 | 0.77 | NPC1 (0.61) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL5994851 | 0.76 | NPC1 (0.56) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL1193017 | 0.75 | NPC1 (0.63) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL12895806 | 0.74 | NPC1 (0.60) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL1193628 | 0.72 | ALDH1A1 (0.60) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL8393025 | 0.72 | NPC1 (0.57) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL1193623 | 0.72 | ALOX5 (0.56) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL8213292 | 0.69 | MTNR1A (0.47) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL31084267 | 0.69 | NPC1 (0.67) | NPC1POLBMEN1MAPTKMT2A | |
| SCHEMBL7774453 | 0.69 | NPC1 (0.67) | NPC1POLBMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046757-A1 | AMINOMETHYL-4-IMIDAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |