Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209442 | 0.85 | KDM1A (0.43) | RAB9AMMP1MMP13KDM1ASMN1; SMN2 | |
| SCHEMBL8213085 | 0.83 | MMP13 (0.46) | POLBRAB9AMMP1MMP13PARP10 | |
| SCHEMBL8209387 | 0.83 | S1PR5 (0.42) | RAB9AL3MBTL1MAOAMAOBKMT2A | |
| SCHEMBL8210831 | 0.82 | BTK (0.35) | MMP1MMP13MAOAMAOBKDM1A | |
| SCHEMBL8209192 | 0.81 | MMP13 (0.49) | GAARAB9AMMP13MAOAMAOB | |
| SCHEMBL8208991 | 0.81 | NPC1 (0.41) | RAB9AMAOAMAOBKMT2AKDM1A | |
| SCHEMBL8213082 | 0.80 | MEN1 (0.44) | POLBKMT2ATSHRSMN1; SMN2CA1 | |
| SCHEMBL8212956 | 0.78 | MMP13 (0.42) | POLBMMP1MMP13MAOBKMT2A | |
| SCHEMBL8208997 | 0.78 | MAOB (0.42) | POLBRAB9AMAOAMAOBPARP10 | |
| SCHEMBL8211587 | 0.77 | S1PR1 (0.42) | MAOAMAOBKMT2AKDM1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | claimed |
| JP-2000143625-A | 5-OXOPYRROLIDINE-2-CARBOXYLIC ACID HYDROXYAMIDE DERIVATIVE | PFIZER PROD INC | 2000-05-26 | — | — | JP | disclosed |