Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 5/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27618779 | 0.81 | ENPP3 (0.49) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL2438565 | 0.75 | ENPP3 (0.63) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL8228630 | 0.75 | ENPP3 (0.58) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL8418313 | 0.73 | ENPP3 (0.56) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL8257975 | 0.73 | ENPP3 (0.56) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL10263247 | 0.73 | ENPP3 (0.59) | ENPP3ENPP1SCN9AKMT2AMAPT | |
| SCHEMBL6986241 | 0.72 | ENPP3 (0.69) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL12021820 | 0.71 | ENPP3 (0.53) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL13450985 | 0.71 | ENPP3 (0.53) | ENPP3ENPP1SCN9AKMT2APOLB | |
| SCHEMBL8221400 | 0.71 | ENPP3 (0.53) | ENPP3ENPP1SCN9AKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968194-A1 | ATROPISOMERS OF 3-ARYL-4(3H)-QUINAZOLINONES AND THEIR USE AS AMPA-RECEPTOR ANTAGONISTS | Pfizer Products Inc. (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0901487-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1998038173-A1 | ATROPISOMERS OF 3-ARYL-4(3H)-QUINAZOLINONES AND THEIR USE AS AMPA-RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 1998-09-03 | — | — | WO | disclosed |
| WO-1997043276-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1997-11-20 | — | — | WO | disclosed |