Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529461 | 0.85 | KMT2A (0.49) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7518699 | 0.85 | MAOA (0.51) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL7521962 | 0.85 | ALDH1A1 (0.51) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7524755 | 0.84 | SMN1; SMN2 (0.55) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7525033 | 0.81 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7517281 | 0.80 | KMT2A (0.62) | MAPTKMT2AMEN1PTPN7 | |
| SCHEMBL7560746 | 0.79 | KDM4E (0.46) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7518438 | 0.78 | EPHX1 (0.61) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7515289 | 0.76 | MAPT (0.45) | RAB9ANPC1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL1275920 | 0.76 | ALDH1A1 (0.70) | RAB9ANPC1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009747-A1 | UREIDO AND THIOUREIDO DERIVATIVES OF 4-AMINO-2(5H)-FURANONES AND 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999012917-A1 | UREIDO AND THIOUREIDO DERIVATIVES OF 4-AMINO-2(5H)-FURANONES AND 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-18 | — | — | WO | disclosed |