Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.42 |
| ▸ | FNTB | P49356 | 6/20 | 0.42 |
| ▸ | CYP51A1 | Q16850 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7654320 | 0.91 | FNTA (0.53) | FNTAFNTBPGGT1BTDP1 | |
| SCHEMBL7669307 | 0.90 | FNTA (0.45) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7656231 | 0.89 | FNTA (0.49) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7660388 | 0.88 | FNTA (0.56) | FNTAFNTBPGGT1BTDP1 | |
| SCHEMBL7660594 | 0.86 | CYP3A4 (0.43) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7667473 | 0.86 | FNTA (0.54) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL8224926 | 0.82 | FNTA (0.43) | FNTAFNTBCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7656241 | 0.82 | CYP51A1 (0.40) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7656236 | 0.82 | FNTA (0.49) | FNTAFNTBCYP51A1CYP3A4CYP2D6 | |
| SCHEMBL7656582 | 0.81 | CYP51A1 (0.49) | CYP51A1CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | claimed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | claimed |
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |