Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP51A1 | Q16850 | 6/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7653706 | 0.89 | PTGS2 (0.47) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7665403 | 0.84 | CYP19A1 (0.41) | CYP51A1PTGS2CYP19A1AURKAPDPK1 | |
| SCHEMBL7654320 | 0.83 | FNTA (0.53) | — | |
| SCHEMBL7657896 | 0.82 | CYP51A1 (0.44) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7656236 | 0.82 | FNTA (0.49) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7669388 | 0.81 | CYP51A1 (0.40) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7669380 | 0.81 | CYP51A1 (0.40) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7662078 | 0.81 | FNTA (0.49) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7659533 | 0.81 | CYP51A1 (0.46) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL8211342 | 0.81 | FNTA (0.42) | CYP51A1PTGS2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410539-B1 | ANTICARCINOGENIC AGENTS | ASTRAZENCA UK LIMITED (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |