Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8211399 | 0.78 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL4890377 | 0.66 | ACP1 (0.49) | CRHR1 | |
| SCHEMBL8209805 | 0.65 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL805589 | 0.65 | HSD11B1 (0.51) | CRHR1 | |
| SCHEMBL8213282 | 0.64 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL9080502 | 0.64 | CYP1A2 (0.45) | CRHR1 | |
| SCHEMBL8210968 | 0.63 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL8208448 | 0.63 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL805590 | 0.62 | HSD11B1 (0.51) | — | |
| SCHEMBL13990192 | 0.61 | TSHR (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103737-A | Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-15 | — | — | US | claimed |
| US-6103737-A | Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0994860-A1 | ARYL-AND ARYLAMINO-SUBSTITUTED HETEROCYCLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1999001439-A1 | ARYL-AND ARYLAMINO-SUBSTITUTED HETEROCYCLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-01-14 | — | — | WO | disclosed |