Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199988 | 0.91 | ALDH1A1 (0.37) | SMN1; SMN2MAPTALDH1A1HTTPTPN1 | |
| SCHEMBL8210397 | 0.91 | KDM4E (0.41) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8200396 | 0.90 | ALDH1A1 (0.44) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8198895 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8200375 | 0.89 | ALDH1A1 (0.41) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8199938 | 0.88 | ALDH1A1 (0.38) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8211924 | 0.84 | F11 (0.36) | SMN1; SMN2HPGDMAPTALDH1A1GAA | |
| SCHEMBL8212479 | 0.83 | MAPT (0.38) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8207755 | 0.82 | GRIN2C (0.48) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 | |
| SCHEMBL8200038 | 0.81 | NPC1 (0.37) | SMN1; SMN2KDM4EHPGDMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |