Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886983 | 0.90 | NR1H4 (0.51) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8210714 | 0.87 | KDM4E (0.51) | MEN1KMT2ASMN1; SMN2KDM4ESCD | |
| SCHEMBL8206330 | 0.86 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2KDM4ESCD | |
| SCHEMBL8206984 | 0.85 | ALDH1A1 (0.54) | MEN1KMT2ASMN1; SMN2KDM4ESCD | |
| SCHEMBL8198891 | 0.83 | TDP1 (0.53) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4749069 | 0.77 | KMT2A (0.74) | MEN1KMT2ASMN1; SMN2KDM4ECA1 | |
| SCHEMBL7888371 | 0.77 | MAPK1 (0.53) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8207400 | 0.77 | CNR2 (0.49) | MEN1KMT2ASMN1; SMN2KDM4EL3MBTL1 | |
| SCHEMBL8207961 | 0.77 | MGLL (0.53) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8198895 | 0.77 | SMN1; SMN2 (0.38) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |