Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731571 | 0.85 | CNR1 (0.43) | TRPM5ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL8215059 | 0.81 | GRM1 (0.40) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8215134 | 0.72 | ITK (0.35) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL2136784 | 0.71 | MGAM (0.50) | TRPM5ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL2136780 | 0.71 | MGAM (0.50) | TRPM5ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL8219547 | 0.70 | CNR2 (0.35) | ALDH1A1NPC1RAB9AMEN1MAPT | |
| SCHEMBL6085541 | 0.70 | HSD11B1 (0.44) | ALDH1A1NPC1RAB9AMEN1TP53 | |
| SCHEMBL8215561 | 0.70 | HSD11B1 (0.45) | ALDH1A1RAB9AMEN1CYP3A4MAPT | |
| SCHEMBL8212845 | 0.68 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8211978 | 0.68 | GRM1 (0.40) | GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |