Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MST1R | Q04912 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 5/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215082 | 0.93 | HPGDS (0.42) | HPGDS | |
| SCHEMBL4729426 | 0.88 | ALDH1A1 (0.49) | ALDH1A1F2GLAHPGDAURKA | |
| SCHEMBL8213684 | 0.87 | PDGFRB (0.46) | GRM1PDGFRBPDGFRA | |
| SCHEMBL8215059 | 0.85 | GRM1 (0.40) | ALDH1A1GRM1NPC1RAB9AMEN1 | |
| SCHEMBL8211978 | 0.81 | GRM1 (0.40) | GRM1 | |
| SCHEMBL4728861 | 0.80 | HPGDS (0.46) | ITKGRM1HPGDS | |
| SCHEMBL8215134 | 0.79 | ITK (0.35) | ALDH1A1HPGDITKGRM1HSD11B1 | |
| SCHEMBL8215665 | 0.75 | RXRA (0.36) | ALDH1A1GRM1NPC1 | |
| SCHEMBL4729407 | 0.74 | PDGFRB (0.48) | ALDH1A1GRM1MEN1KMT2APDGFRB | |
| SCHEMBL8219547 | 0.72 | CNR2 (0.35) | ALDH1A1HPGDGRM1HSD11B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035049-A1 | ADAMANTANYL-(CYCLOPROPYL)-KETONES AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-03-27 | — | — | WO | disclosed |