SCHEMBL8213819

SCHEMBL8213819

CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CC(C)C)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 9/20 0.56
NPY1R P25929 7/20 0.56
NPY2R P49146 5/20 0.56
FOLH1 Q04609 1/20 0.53
ACE P12821 4/20 0.52
NPY5R Q15761 4/20 0.50
MME P08473 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8213821 1.00 NPY4R (0.56) NPY4RNPY1RNPY2RFOLH1ACE
SCHEMBL7033970 0.97 NPY4R (0.57) NPY4RNPY1RNPY2RFOLH1ACE
SCHEMBL413803 0.93 NPY4R (0.56) NPY4RNPY1RNPY2RACENPY5R
SCHEMBL413804 0.93 NPY4R (0.56) NPY4RNPY1RNPY2RACENPY5R
SCHEMBL6565110 0.92 GNPAT (0.53) NPY4RNPY1RNPY2RACEMME
SCHEMBL1477244 0.91 MME (0.54) NPY4RNPY1RNPY2RACEMME
SCHEMBL8727951 0.91 MME (0.54) NPY4RNPY1RNPY2RACEMME
SCHEMBL9197350 0.88 NPY4R (0.62) NPY4RNPY1RNPY2RNPY5R
SCHEMBL27794742 0.86 NPY4R (0.54) NPY4RNPY1RNPY2RFOLH1ACE
SCHEMBL27066398 0.85 FPR1 (0.56) NPY4RNPY1RNPY2RFOLH1ACE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6103691-A ADMINISTERING AN AGENT CONTAINING ONE OR MORE ACTIVE INGREDIENTS SELECTED FROM THE GROUP CONSISTING OF ANGIOGENINE, ALPHA1-MICROGLOBULIN, COMPLEMENT FACTOR D, FRAGMENTS OR PEPTIDES TSCHESCHE HARALD (DE) 2000-08-15 US disclosed
EP-0689448-B1 ANGIOGENINE, AND/OR ALPHA1-MICROGLOBULINE AND/OR COMPLEMENTARY FACTOR D FOR LIMITING PROTEIN SECRETION TSCHESCHE HARALD (DE) 1997-12-03 EP disclosed