Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215440 | 0.90 | KMT2A (0.43) | PIK3CAMTORPIK3CGKMT2ACA2 | |
| SCHEMBL8213062 | 0.89 | PIK3CD (0.49) | PIK3CAMTORPIK3CGKMT2ACA2 | |
| SCHEMBL8214025 | 0.86 | EPHX1 (0.47) | ALDH1A1KMT2ACA2CA9CA12 | |
| SCHEMBL8205334 | 0.86 | PIK3CA (0.41) | PIK3CAMTORPIK3CGKMT2ACA2 | |
| SCHEMBL8214032 | 0.85 | ATM (0.45) | ALDH1A1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8214220 | 0.85 | PIK3CA (0.48) | ALDH1A1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8204669 | 0.85 | KMT2A (0.45) | ALDH1A1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8214694 | 0.81 | PIK3CA (0.38) | ALDH1A1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8219083 | 0.81 | NAMPT (0.40) | ALDH1A1PIK3CAMTORPIK3CGKMT2A | |
| SCHEMBL8205299 | 0.80 | PIK3CD (0.48) | PIK3CAMTORPIK3CGKMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |